Garcinol is a polyisoprenylated benzophenone derived from the Garcinia indica fruit that possess potential therapeutic effects such as inhibition of inflammation and tumor expansion.Here, we investigated whether garcinol induces TRAIL sensitization in renal carcinoma cells.Single treatment with garcinol or TRAIL did not effect on apoptosis.However,
Relative robustness of NOEC and ECx against large uncertainties in data.
The relative ability of Mushroom Bag the NOEC (no-observed-effect concentration) and ECx (the effect concentration corresponding to x-percent response) to determine benchmark toxicant concentrations, which are expected to ensure environmental safety, when there are large uncertainties in data was investigated with Monte Carlo simulations.We assumed
Investigating the Migraine Cycle over 21 Consecutive Days Using Proton Magnetic Resonance Spectroscopy and Resting-State fMRI: A Pilot Study
Recent neuroimaging studies have revealed important aspects of the underlying pathophysiological mechanisms of migraine suggesting abnormal brain energy metabolism and altered functional connectivity.Proton magnetic resonance spectroscopy (1H-MRS) studies investigated migraine patients in the interictal or ictal state.This first-of-its-kind study a